Peripheral neuropathy describes damage to the nerves of the peripheral nervous system with primary causes being trauma, tumors or the side effects of systemic disease (e.g. diabetes). It is estimated that about 5% of population has some form of neuropathy and there is up to 5% incidence of peripheral nerve injuries in admissions to a level I trauma center. Furthermore, according to recent studies, approximately half of all patients with type II diabetes mellitus develop diabetic neuropathy. Clinical evaluation of peripheral neuropathies has traditionally relied on clinical examination and electrodiagnostic testing. However, these methods can frequently provide incomplete information about the anatomy and degree of peripheral neuropathy. MR neurographic techniques enable the non-invasive morphological and functional imaging of the peripheral nervous system.
Our peripheral nerves MRI research focuses on the following directions:
Nico Sollmann, Elisabeth Klupp
PD Dr. J. Kirschke, Prof. K. Woertler, Dr. A. Gersing
B. Cervantes, J. S. Kirschke, E. Klupp, H. Kooijman, P. Börnert, A. Haase, E. J. Rummeny, D. C. Karampinos, Orthogonally combined motion- and diffusion-sensitized driven equilibrium (OC-MDSDE) preparation for vessel signal suppression in 3D TSE imaging of peripheral nerves in the extremities, Magnetic Resonance in Medicine, in press
Cervantes, B., Bauer, J.S., Zibold, F., Kooijman, H., Settles, M., Haase, A., Rummeny, E.J., Wörtler, K., Karampinos, D.C., Imaging of the Lumbar Plexus: Optimized Refocusing Flip Angle Train Design for 3d Tse. Journal of Magnetic Resonance Imaging 43, 789–799.
Karampinos, D.C., Melkus, G., Shepherd, T.M., Banerjee, S., Saritas, E.U., Shankaranarayanan, A., Hess, C.P., Link, T.M., Dillon, W.P., Majumdar, S., Diffusion Tensor Imaging and T 2 Relaxometry of Bilateral Lumbar Nerve Roots: Feasibility of In-Plane Imaging. NMR in Biomedicine 26, n/a-n/a.