Body Magnetic Resonance Research Group

Diffusion-weighted MRI and MRS

Research summary

Our technical work on diffusion-weighted MRI and MRS focuses on the following directions:

  • Development of diffusion acquisition techniques to overcome the limitations of single-shot EPI.
  • Development of diffusion signal modeling techniques.
  • Removal of the confounding effect of fat in diffusion measurements of the water component in tissues (e.g. skeletal muscle, bone marrow).
  • Development of high b-value DW-MRS to measure diffusion properties of fat and adipose tissue.

Key publications

  • Dieckmeyer, M., Ruschke, S., Eggers, H., Kooijman, H., Rummeny, E. J., Kirschke, J. S., … Karampinos, D. C. Adc Quantification of the Vertebral Bone Marrow Water Component: Removing the Confounding Effect of Residual Fat. Magnetic Resonance in Medicine.

  • Karampinos, D. C., Banerjee, S., King, K. F., Link, T. M., & Majumdar, S. Considerations in High-Resolution Skeletal Muscle Diffusion Tensor Imaging Using Single-Shot Echo Planar Imaging With Stimulated-Echo Preparation and Sensitivity Encoding. NMR in Biomedicine, 25(5), 766–778.

  • Hernando, D., Karampinos, D. C., King, K. F., Haldar, J. P., Majumdar, S., Georgiadis, J. G., & Liang, Z.-P. Removal of Olefinic Fat Chemical Shift Artifact in Diffusion Mri. Magnetic Resonance in Medicine, 65(3), 692–701.

  • Karampinos, D. C., King, K. F., Sutton, B. P., & Georgiadis, J. G. Intravoxel Partially Coherent Motion Technique: Characterization of the Anisotropy of Skeletal Muscle Microvasculature. Journal of Magnetic Resonance Imaging, 31(4), 942–953.

  • Valentinitsch, A., Karampinos, D. C., Alizai, H., Subburaj, K., Kumar, D., Link, T. M., & Majumdar, S. Automated Unsupervised Multi-Parametric Classification of Adipose Tissue Depots in Skeletal Muscle. Journal of Magnetic Resonance Imaging, 37(4), 917–927.

  • Karampinos, D. C., Van, A. T., Olivero, W. C., Georgiadis, J. G., & Sutton, B. P. High-Resolution Diffusion Tensor Imaging of the Human Pons With a Reduced Field-Of-View, Multishot, Variable-Density, Spiral Acquisition At 3 T. Magnetic Resonance in Medicine, 62(4), 1007–1016.