Body Magnetic Resonance Research Group

Water–fat imaging and fat quantification

Research summary

Our technical work on water–fat imaging and fat quantification focuses on the following directions:

  • Development of SNR-efficient multi-echo gradient echo acquisition techniques for water–fat separation.
  • Robust fieldmap estimation in water–fat separation.
  • Removal of confounding effects in PDFF quantification using both imaging- and MRS-based techniques.
  • Development of MRS techniques to measure fat unsaturation.

Key publications

  • Ruschke, S., Eggers, H., Kooijman, H., Diefenbach, M. N., Baum, T., Haase, A., … Karampinos, D. C. Correction of Phase Errors in Quantitative Water–Fat Imaging Using a Monopolar Time-Interleaved Multi-Echo Gradient Echo Sequence. Magnetic Resonance in Medicine.

  • Ruschke, S., Kienberger, H., Baum, T., Kooijman, H., Settles, M., Haase, A., … Karampinos, D. C. Diffusion-Weighted Stimulated Echo Acquisition Mode (dw-Steam) Mr Spectroscopy To Measure Fat Unsaturation in Regions With Low Proton-Density Fat Fraction. Magnetic Resonance in Medicine, 75(1), 32–41.

  • Karampinos, D. C., Ruschke, S., Dieckmeyer, M., Eggers, H., Kooijman, H., Rummeny, E. J., … Baum, T. Modeling of T 2 * Decay in Vertebral Bone Marrow Fat Quantification. NMR in Biomedicine, 28(11), 1535–1542.

  • Karampinos, D. C., Melkus, G., Baum, T., Bauer, J. S., Rummeny, E. J., & Krug, R. Bone Marrow Fat Quantification in the Presence of Trabecular Bone: Initial Comparison Between Water-Fat Imaging and Single-Voxel Mrs. Magnetic Resonance in Medicine, 71(3), 1158–1165.

  • Karampinos, D. C., Yu, H., Shimakawa, A., Link, T. M., & Majumdar, S. Chemical Shift-Based Water/fat Separation in the Presence of Susceptibility-Induced Fat Resonance Shift. Magnetic Resonance in Medicine, 68(5), 1495–1505.

  • Karampinos, D. C., Yu, H., Shimakawa, A., Link, T. M., & Majumdar, S. T1-corrected Fat Quantification Using Chemical Shift-Based Water–fat Separation: Application To Skeletal Muscle. Magnetic Resonance in Medicine, 66(5), 1312–1326.